Pia Mancini is one of the founders of the Net Party, a political party headquartered in Argentina. She is also a co-founder of DemocracyOS, which is for free source decisions in order to give more weight to the opinions of citizens (direct democracy). Her political goal is to make a "democracy of the 21st century" that would result in greater impact of citizens in politics, notably through new technologies, with the Internet as the main element.

Her TED talk, How to Upgrade Democracy for the Modern Era, garnered over a million views. She is currently involved in efforts to port the DemocracyOS system to a number of different countries, via a number of different political organisations.